Séminaire de Anne-Karine BOUZIER-SORE, Centre de Résonance Magnétique des Systèmes Biologiques (CNRS-Université de Bordeaux/Segalen) organisé par le GIN dans le cadre des séminaires du Pôle.

Jeudi 18 octobre 2012 à 11h30 au GIN Chemin Fortune Ferrini CHU, La Tronche

Functional neuro-energetic and brain imaging: the power of MRS to understand how astrocytes contribute to the signal
Intervenante : 

Thèmes de recherche de l'intervenante : RMN du système nerveux sain ou pathologique. Mécanismes de couplage entre activité cérébrale et métabolisme énergétique, liens neurones et astrocytes.

Résumé du séminaire : Brain possesses intrinsic mechanisms that allow the regulation of its major substrate, i.e. glucose, both for its contribution and its utilization depending on local cerebral activity variations. Despite the general recognition of this principle, the cellular and molecular mechanisms that underlie such a tight relationship between neuronal activity and energetic metabolism are still unknown and highly debated. More than 100 years ago, Camillo Golgi suggested, at the sight of their cyto-architectural connexions with endothelium cells and neurons, that astrocytes could play a central role in the distribution of energetic substrates between blood vessels and neurons. During the last 10 years, series of studies have been performed, both in vitro and in vivo, and have led to the recognition of the major role that astrocytes seem to play in brain energetic metabolism and have revealed a part of the mechanisms that come into play. Talk will focus on data obtained by NMR spectroscopy. This technique has provided results that give us a glimpse on the way astrocytes participate to neuronal energetic needs during cerebral activity.